Hailey-Hailey disease
The cause of the disease is a defect in the calcium pump gene which is located on chromosome 3.
This causes the cells of the skin to not adhere together properly, causing the blisters and rashes. There is no cure.

Treatment

Topical steroid preparations have some effect during outbreaks, but do not stop them. Drugs such as antibiotics, antifungals, corticosteroids, dapsone, methotrexate, thalidomide, etretinate, cyclosporine and, most recently, intramuscular alefacept may control the disease but are ineffective for severe chronic or relapsing forms of the disease. Injections of botulinum toxin to inhibit perspiration may help. Maintaining a healthy weight, avoiding heat and friction of affected areas, and keeping the area clean and dry work about as well.

Some have found relief in laser resurfacing that burns off the top layer of the epidermis, allowing healthy non-affected skin to re-grow in its place.

Secondary bacterial, fungal and/or viral infections are common and may exacerbate an outbreak. Some patients have found that outbreaks are triggered by certain foods, hormone cycles and stress.

Palmar-Plantar Keratodermas

Pachyonychia Congenita

Extensive Epidermal Nevi

Erthrokeratodermas

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